i think it's very hard to justify 1 450i.
again, what is the lab size? how many units do you want to produce a day, what types of restorations are you doing... etc etc...
in terms of learning curve, that is also a loaded question because a competent person will find delcam and sum3d all easy to use.
In terms of accuracy, yes, the more expensive mills will be more accurate. There is apparently better accuracy with wet milling as well over dry milling (even zirconia). Jager spindles are tough, but again, depends on which model jager you get for the mill.
Tool life depends on what you are cutting, depends on the strategies you use...etc etc...
i love all machines...as long as it is the right tool for the job.