I have been doing splints from digital medium for the last 4 years and we have found a few ways of doing them that have given us great results.
We looking into milling, but it was time consuming and tedious when we use all of our mills currently and couldn't dedicate any to milling splints (Also the material we tried didn't compare to our standard material we prefer to use).
The best strategy we have found is a method i developed where we design the splints digitally (Either from ios scan or physically scanned models) and then reverse engineer a mold from that splint. We then print the mold and then can easily use our preferred flow-able acrylics to give us an extremely accurate splint that has minimal trimming requirements once out of the pressure pot. We have even seen better overall results since the acrylic is blocked from any contaminants in the water, we have noticed clearer and more aesthetically pleasing splints come from this method. This method has also allowed us to use fully flow-able materials in the splint deigns, where usually we would have to do the surface in a harder acrylic to ensure that the acrylic wouldn't flow out, or have to wax walls extremely high.
We also do make some splints physical based from ios scans, where we print and mount the models and then proceed with either digital or physical production. With 3Shape calibration objects, we can ensure that articulations are consistent across the design and has lead to really accurate splints, not to mention the finishing time on our splints has decreased significantly.
We ask doctors to either send a physical bite, or scan with the bite they would like. If they do the later we can design a bite guide digitally and then mount the models accordingly for more complex splints.