Of course you can invent a way to hold whatever material wherever you want, and mill it!
Or, if you have open CAM, you simply move your material coordinants (raw curves) to match what you have in the milling chamber. We move things around often. It is a wee-bit tricky, and you may want to "Ghost-Mill" a few times, or practice on softer materials just in case you slam down on a tool. Whoops!
Bar of soap? Piece of foam? Chunk of soft wax?
Piece of Hubba-Bubba bubble gum? (just kidding, but that's what eMax reminds me of)