From University of Iowa, under troubleshooting dentures:
"Speech Problems
It takes patients from 2 – 3 weeks to accustom themselves to dentures, so it is difficult to judge this early on, but some things to think about are:
Patients are adaptable and generally will correct speech difficulties (not directly related to technical error) within 2 or 3 weeks, so most patients can be assured they will get past the difficulty
The pronunciation of the letter "s" is the most common speech problem; the patient may even have involuntary hissing or whistle. This can be caused by:
Rugae area too thick or too thin or the maxillary anterior teeth may be set too far lingually. If the patient has a heavy anterior ridge and the denture is thick, the rugae area should be thinned to allow more space for air to escape. If the anterior ridge is small and thin, likely too much air is escaping and wax on the palatal surface should correct the problem (autopolymerizing resin can then be added if the wax shows this to be an effective correction). If the maxillary anterior teeth are set too lingually, they must be reset or you may try heavy festooning just lingual to the teeth. If these remedies don’t work, sometimes adding a median ridge will help.
Inability to speak clearly may be due to the lack of tongue room posteriorly on the mandibular denture.
Overextension of the upper denture onto the soft palate results in speech difficulties, as the patient has to make a conscious effort to keep the denture in position when talking."