Cam software has no limitation, the only limitation on putting angled holes in is on the mill. Most cad software will ouput a second file for use in locating the holes, this is the most accurate way to mill implants. 3Shape outputs an xml file, exocad has what they refer to as a construction file. Most cam software have an alternative way of placing the implant for the holes also, this is a less accurate way because it is just aligning with the hole, Have you toke a good look at what some of the output files look like, (stl) these are just assumption, and yes they can be accureate enough to use I have done plenty of bars without having the placement files and doing it buy what i call manually placing. I don't ever mill the implant geometry that is actuallly on the bar it mills to a template that is placed onto the bar. I big problem with doing anything with multiple implants is the accuracy of the scan bodies, be careful of this, especially those of you with exocad I know there are junk scan bodies being used that work fine for abutment but wont ever makeing a nice fitting bar.